Cerebral processing of emotions in phantom eye pain patients: An event related potential study

Phantom eye pain (PEP) is a major clinical problem after removal with no standard treatment protocol to date. As multidimensional experience associated emotional and cognitive components, this study aimed explore the possible neuropsychological mechanisms of PEP in perspective cognition, order provide basis for treatment. Visual oddball event-related potentials (ERPs) under different external stimuli (Disgust, Fear, Sadness, Happiness, Erotica Neutral) were tested 12 patients healthy volunteers. Participants' affective states measured Mood Disorder Questionnaire (MDQ), Hypomania Checklist-32 (HCL-32), Plutchik–van Praag Depression Inventory (PVP). The amplitudes latencies N1, P2, N2 P3 components analyzed by three-way ANOVA, i.e., group (2) ​× ​emotion (6) ​electrode (3). Multiple comparisons performed using Bonferroni's test. Longer N1 latencies, increased amplitudes; shorter P2 Disgust decreased Erotica, found compared controls. There was main effect or interaction on amplitudes. MDQ HCL-32 scores lower, Sadness negatively correlated PVP patients. showed reversed patterns exogenous attention allocation enhanced involuntary This demonstrated cortical processing emotions could developing intervention therapy.